Lily Tomlin

Ms. Frizzle (voice)

Daniel DeSanto

Carlos (voice)

Stuart Stone

Ralphie (voice)

Danny Tamberelli

Arnold Perlstein (voice)

Erica Luttrell

Keesha (voice)

Lisa Yamanaka

Wanda (voice)

Tara Meyer

Dorothy Ann (voice)

Maia Filar

Phoebe (voice)

Andre Ottley-Lorant

Tim (voice)

Malcolm-Jamal Warner

The Producer (voice)