Bob Hoskins

Eddie Valiant

Christopher Lloyd

Judge Doom

Joanna Cassidy

Dolores

Charles Fleischer

Roger Rabbit / Benny the Cab / Greasy / Psycho (voice)

Kathleen Turner

Jessica Rabbit (voice) (uncredited)

Stubby Kaye

Marvin Acme

Alan Tilvern

R.K. Maroon

Richard LeParmentier

Lt. Santino

Lou Hirsch

Baby Herman (voice)

Betsy Brantley

Jessica's Performance Model

Joel Silver

Raoul

Paul Springer

Augie