Basil Rathbone

Sherlock Holmes

Nigel Bruce

Doctor Watson

Lionel Atwill

Professor Moriarty

William Post Jr.

Dr. Franz Tobel

Kaaren Verne

Charlotte Eberli

Dennis Hoey

Inspector Lestrade

Holmes Herbert

Sir Reginald

Mary Gordon

Mrs. Hudson

Harry Cording

Jack Brady (uncredited)

Harold De Becker

Peg Leg (uncredited)

Paul Fix

Mueller (uncredited)

Henry Victor

Professor Frederic Hoffner (uncredited)