Owen Wilson

Reggie (voice)

Woody Harrelson

Jake (voice)

Amy Poehler

Jenny (voice)

George Takei

S.T.E.V.E. (voice)

Colm Meaney

Myles Standish (voice)

Keith David

Chief Broadbeak (Voice)

Dan Fogler

Governor William Bradford (voice)

Jimmy Hayward

Ranger / Leatherbeak / President / Hazmats (voice)

Jeff Biancalana

General Sagan / Hazmats (voice)

Danny Carey

Danny (voice)

Carlos Ponce

Narrator / Alejandro (voice)

Robert Beltran

Chief Massasoit (voice)